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Profil Adenokarsinoma Kolon di RSUP Prof Dr. R. D. Kandou dan Siloam Hospitals Periode Januari – Juni Pemberian Kombinasi 5FU-Leucovorin dengan Phaleria macrocarpa terhadap Proliferasi Sel dan Diameter Adenokarsinoma Kolon Tikus Sprague dawley. PROPOLIS TERHADAP KSPRESI PROTEIN CASPASE 8, APOPTOSIS, DAN PROLIFERASI PADA KULTUR SEL ADENOKARSINOMA KOLON (WiDr).

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P macrocarpa, colon adenocarsinoma, cell proliferation, tumor mass diameter. Converted by the carboxylesterase enzyme to its active metabolite from, SN This page is licensed under a Creative Commons Attribution License. The authors concluded that adjuvant chemotherapy provides significant disease-free survival benefit because it reduces the recurrence rate particularly within the first 2 years of adjuvant therapy but with some benefit in years The addition of anti-EGFR antibody treatment to standard chemotherapy regimens for patients with advanced colorectal cancer improves progression-free survival for those with wild-type but not mutant KRAS status.

Fulda S, Debatin KM. Protective Effect of Caffeic Acid Phenethyl. Ongoing adjuvant trials are investigating additional risk stratification of stage II colon cancer based on clinicopathological and molecular markers ECOG trial.

Elderly patients benefited to a similar degree as younger patients. Penelitian ini bertujuan adfnokarsinoma mengkaji efek anti kanker ekstrak ethanol propolis EEP yang berasal dari Kerjo, Karanganyar, Indonesia pada kultur sel adenokarsinoma kolorektal cell line WiDr melalui pengaruhnya terhadap ekspresi protein Caspase 8, apoptosis dan proliferasi sel.

The National Academic Press; Colon tumors induced by 1,2-DMH subcutaneously.

Boerl on Human Cancer Cell Lines. Bokemeyer et al examined the overall response rate when combining cetuximab with oxaliplatin, leucovorin, and fluorouracil FOLFOX-4as opposed to the regimen without cetuximab, for first-line treatment of metastatic colorectal cancer in a randomized study.

National Comprehensive Cancer Network, Inc.

Perpustakaan Unika Atma Jaya

The study concluded that adding bevacizumab to fluorouracil-based chemotherapy improved overall survival and progression- free survival in older patients as it does in younger patients, without increased risks of treatment in the older age group. It is also indicated for second-line treatment in patients ,olon have progressed on a first-line bevacizumab-containing regimen.


It is indicated for patients with metastatic colorectal cancer mCRC who have been previously treated with fluoropyrimidine- oxaliplatin- and irinotecan-based chemotherapy; an anti—vascular endothelial growth factor VEGF therapy eg, bevacizumab, ziv-aflibercept ; and, if KRAS wild type, an anti—epidermal growth factor receptor EGFR therapy eg, cetuximab, panitumumab [64].

Journal of Agricultural and Food Chemistry, 52 Shown to be effective in adjuvant setting. Proliferation, Cell Cycle and Apoptosis in Cancer. Binds to and stabilizes ternary complex of FdUTP intracellular active metabolite of fluoropyrimidines and thymidylate synthetase TSaugmenting cytotoxic effects of 5-fluorouracil.

Levamisole is no longer an appropriate component of adjuvant therapy. Surgery remains the top choice therapy with other modalities such as chemotherapy, radiation and immunotherapy as P macrocarpa Mahkota Dewa.

This study seeks to prove the effects of fruit extracts P macrocarpa against colon adenocarsinoma, especially in terms of cell proliferation and changes in diameter of the tumor mass. Help Center Find new research papers in: Evid Based Complement Alternat Med, 2 1: Jurnal Kedokteran Brawijaya, Vol 29, No. Undergoes hydrolysis in liver and tissues to form the active moiety fluorouracilinhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to th Leucovorin Folinic acid, Citrovorum Factor Reduced form of folic acid that does not require enzymatic reduction reaction for activation.

Cetuximab may be used as monotherapy or in combination with irinotecan Camptosar in patients with metastatic colorectal cancer refractory to fluoropyrimidine and oxaliplatin therapy. European Journal of Cancer Antimicrobial Agents and Chemotherapy, p. Story M, Kodym R.


For continuation therapy, use bevacizumab in combination with a fluoropyrimidine eg, 5-FU, capecitabine plus irinotecan or oxaliplatin-based chemotherapy Panitumumab Vectibix Recombinant human IgG2 kappa monoclonal antibody that binds kklon human epidermal growth factor receptor EGFR.

Conclusion P macrocarpa has the potential as immunostimulatory which can increase the effectiveness of 5FU-leucovorin chemotherapy in terms lowering the cell proliferation and decrease the diameter of adenocarsinoma colon of Sprague dawley rat. Approval for continuation treatment was based on a study that showed maintenance of VEGF inhibition adennokarsinoma bevacizumab plus standard second-line chemotherapy beyond disease progression has clinical benefits in patients with metastatic colorectal cancer.


Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC.

Jurnal e-CliniC (eCl)

ABC of colorectal cancer, 2nd ed. Statistically significant benefit in overall survival and progression- free survival was observed for regorafenib over placebo in patients with mCRC in whom all approved standard therapies have failed. User Username Password Remember me.

Method Laboratory experimental research with post-test only design. Surat Data Aednokarsinoma Penulis. Tumor kolon diperoleh dengan induksi 1,2-DMH subkutan.

Bevacizumab is indicated in combination with a fluoropyrimidine-based chemotherapy as adenokarsnoma first-line or second-line treatment for metastatic colorectal cancer. This study used a female Sprague dawley white rats were divided into 4 groups: Abstract Insidensi kanker kolon di seluruh dunia masih tinggi dan menjadi penyebab kematian terbanyak kategori penyakit tidak menular.

Also indicated for previously untreated advanced colorectal cancer in combination with 5-FU and leucovorin. Jurnal Kedokteran Media Medika Indonesiana.

A prospective observational study involving patients from the CALGB adjuvant trial demonstrated adverse effect with regards to risk for recurrence and increased mortality for patients following a “Western” diet high intake of red meat, refined grains, fat, and sweets compared to patients with a “prudent” diet high intake of fruits and vegetables, poultry, and fish. Penelitian ini merupakan penelitian experimental laboratories, post test with control group design.

Journal Medicine Food, 14 6: Adenokasinoma standard therapy for colon cancer involves combination chemotherapy. A Cell Cycle Defect.