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Patogenesis. Sindrom antibodi antifosfolipid merupakan gangguan autoimun yang ditandai dengan antibodi dalam sirkulasi yang melawan fosfolipid membran. SAPPORO CRITERIA Sindrom antifosfolipid haruslah memenuhi kriteria yang diputuskan oleh para ahli pada simposium internasional ke-8 tentang antibodi. Posts – See Instagram photos and videos from ‘antifosfolipid’ hashtag. ➡ ️Antifosfolipid sindrom və hamiləlik⬅ Antifosfolipid sindrom venoz və ya arterial .

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Hypo- coagulability Thrombocytopenia Thrombocytopenic purpura: From Wikipedia, the free encyclopedia.

Presence of genetic thrombophilia may determine the need for anticoagulation therapy. Alternatively, the antibodies may contribute directly to a procoagulant state.

Like many autoimmune diseasesit is more common in women than in men. Diseases of clotting D50—69,74— Archived copy as title Infobox medical condition eindrom All articles with unsourced statements Articles with unsourced statements from Antifosfolupid Articles with unsourced statements from January Antiphospholipid syndrome Synonyms Hughes syndrome [1] Micrograph showing an advanced thrombotic microangiopathyas may be seen in ALPA syndrome.

However, since APS patients appear more subject to recurrent events, prophylactic treatment is recommended for a prolonged period of time. The management of women with APS during pregnancy has generated considerable controversy since they may have a significant chance of succesful pregnancy outcome without treatment. Coagulopathies Rheumatology Autoimmune diseases Neurological disorders Obstetrics Syndromes affecting blood Syndromes antifoefolipid the nervous system.

APS provokes blood clots thrombosis in both arteries and veins as well as pregnancy-related complications sntifosfolipid as miscarriagestillbirthpreterm deliveryand severe preeclampsia.


The primary mission of APS ACTION is to prevent, treat, and cure antiphospholipid antibody aPL associated clinical manifestations through high quality, multicenter, and multidisciplinary clinical research. Women with recurrent miscarriage are often advised to take aspirin sntifosfolipid to start low molecular weight heparin treatment after missing a menstrual cycle. Majalah Kedokteran Indonesia,46 8 The Sapporo APS classification criteriapublished in were replaced by the Sydney criteria in The antiphospholipid syndrome responsible for most of the miscarriages in later trimesters seen in concomitant systemic lupus erythematosus and pregnancy.

Antiphospholipid Syndrome Sindrom Antibodi Antifosfolipid. Primary antiphospholipid syndrome occurs in the absence of any other related disease.

D ICD – Risk factors for qntifosfolipid antiphospholipid syndrome include: The diagnostic criteria require one clinical event i.

Antiphospholipid syndrome – Wikipedia

Retrieved from ” https: Antiphospholipid syndrome can be primary or secondary. Antiphospholipid syndrome or antiphospholipid antibody syndrome APS or APLSis an autoimmunehypercoagulable state caused by antiphospholipid antibodies. In APS patients, the most common venous event is deep vein thrombosis of the antifosfolpiid extremities, and the most common arterial event is stroke. Thus, anti-annexin A5 antibodies increase phospholipid-dependent coagulation steps.

The patient on initial screening will sindrm have been found to have a prolonged APTT that does not correct in an The Johns Hopkins Lupus Center.

Antiphospholipid syndrome

Antiphospholipid syndrome often requires treatment with anticoagulant medication such as heparin to reduce the risk of further episodes of thrombosis and improve the prognosis of pregnancy. Archived PDF from the original on The goal of the prophylactic treatment with warfarin is antifoxfolipid maintain the patient’s INR between 2.

Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein Ca glycoprotein with regulatory function upon the common pathway of coagulation by degradating activated factor V. By using this site, you agree to the Terms of Use and Privacy Policy. The antibodies may be just ‘marker’ of the disorder, antifosfolipd thrombosis and pregnancy loss may results from unknown factors which induce a proagulant state.


Antiphospholipid syndrome APS is a disorder of recurrent vascular thrombosis, pregnancy losses and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies APA. Perpustakaan Badan Penelitian sindroom Pengembangan Kesehatan. Other common findings, although not part of the APS classification criteria, are low platelet countheart valve diseaseand livedo reticularis. This is to prevent patients with transient positive tests due to infection etc.

In pregnant women affected by APS, there is an increased risk of recurrent miscarriageintrauterine growth restrictionand preterm birth. The presence of antiphospholipid antibodies aPL in the absence of blood clots or pregnancy-related complications does not indicate APS see below for the diagnosis of APS.

This is tested for by using a minimum of two coagulation tests that are phospholipid-sensitive, due to the antifosfolipidd nature of the lupus anticoagulant antibodies. Anti-thrombin Lupus anticoagulant Coeliac disease: According to a consensus statement, [11] it is advisable to classify APS into one of the following categories for research purposes:. Views Read Edit View history.